Dewayne - one sealant, perhaps, however priming becomes necessary for different substrates, based on project specific preconstruction test results with your substrates. Avoiding primers is a positive thing in my opinion, and perhaps a reason for so many different sealants.
Wayne has listed a collection of high quality silicones I’ve seen and used numerous times for general applications, however for non-bleed/low stain potential applications (note - preconstruction testing required for manufacturer to standby their “no-stain” claim):
General purpose silicones only capable of +/-25% movement…this is low performing (on par with a polyturethane) and would require doubling the width of a caulk joint to handle the same amount of movement relative to a +/-50% sealant. For a 1/2" of movement, do you want a 1" or 2" sealant joint?